Amyloidosis is a condition that occurs when amyloid, an abnormal protein, accumulates in your tissues and organs, affecting their shape and their function. There are several types of amyloidosis all of which can affect the kidneys. Patients who are on dialysis are at risk for amyloidosis if treatment isn’t removing large proteins from the blood. Dialysis-related amyloidosis develops when the proteins in the blood are deposited in joints and tendons, typically affecting patients on long-term dialysis.  It is a serious health issue that can lead to organ failure. Amyloid build-up in the kidneys can make it difficult for them to do their job.